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The short answer is that it depends on which form of B12 you have

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Because some of the things you might notice, the reduced interest in meals you cook together, the inability to finish food at restaurants, the declining enthusiasm for eating occasions that used to be enjoyable, are not about you

BMC cancer 18, 12301239

The article says the core side effects are shared across manufacturers: nausea, vomiting, constipation, and general gastrointestinal upset, particularly during dose escalation

mRNA expression analysis by real-time PCR Total RNA was isolated from the dissected tissues using the RNeasy Mini kit (Qiagen, CA, USA), followed by reverse transcription using the High Capacity RNA-to-cDNA kit (Thermo Fisher Scientific, Waltham, MA, USA) according to the manufacturers instructions